研究実績一覧仁泉医学目次（昭和31-34年）

  • Wu, H., Fujioka, Y., Sakaguchi, S., Suzuki, Y., Nakano, T. Electron Tomography as a Tool to Study SARS-CoV-2 Morphology. International Journal of Molecular Sciences 25(21), 11762, 2024 (in the Special Issue “Virus Engineering and Application, 2nd Ed.).
  • Wu, H., Fujioka, Y., Sakaguchi, S., Suzuki, Y., Nakano, T.: Morphological analysis for two types of viral particles in vacuoles of SARS‑CoV‑2‑infected cells. Medical Molecular Morphology 57(2) 124-135, 2024.
  • Takayama S, Wu H, Sakaguchi S, Fujioka Y, Suzuki Y, Nakano T. The role of MreB in intrabacterial nanotransportation system for cholera toxin in Vibrio cholerae. Bulletin of Osaka Medical and Pharmaceutical University Vol.68 (1,2) : 17–28, 2022.

  • Wu H, Fujioka Y, Sakaguchi S, Suzuki Y, Nakano T. Three-dimensional reconstruction by electron tomography for the application to ultrastructural analysis of SARS-CoV-2 particles. Med Mol Morphol 55(1) 60-67, 2022.

  • Hayashi, H., Yoshizawa, D., Sogo, M., Sano, K., Nakano, T.: Determination of appropriate sodium chloride concentration for use in preparation of electrolyzed acid water with disinfection potential of osmotic pressure taken into account. Bulletin of the Osaka Medical College 66 (1,2): 9-15, 2020

  • Yoshizawa, D., Hayashi, H., Sogo, M., Sano, K., Nakano, T.: Determination of adequate pH of electrolyzed acidic water for disinfection, under consideration of sub-effective corrosion against metals. Bulletin of the Osaka Medical College 66(1,2): 1-8, 2020

  • Sakaguchi, S., Nakagawa, S., Mitsuhashi, S., Ogawa, M., Sugiyama, K., Tamukai, K., Koide, R., Katayama, Y., Nakano, T., Makino, S., Imanishi, T., Miyazawa, T., Mizutani, T. Molecular characterization of feline paramyxovirus in Japanese cat populations. Archives of Virology 165 (2) 413-418, 2020.

  • Wu H, Iwai N, Suzuki, Y & Nakano T. Molecular association of FtsZ with the intrabacterial nanotransportation system for urease in Helicobacter pylori. Med Mol Morphol. 52(4), 226-234, 2019.

  • Wu H, Suzuki Y, Nakano T, Virus enhancement of the adherence of Helicobacter pylori to host cells. Microscopy, 2018, Vol. 67, No.S2

  • Fujioka Y, Wu H, Suzuki Y, Takada Y, and Nakano T. Evaluation of Platinum Blue as Alternative Stain to Uranyl Acetate in Immunoelectron Microscopy for Bacteria. Bulletin of the Osaka Medical College (Bull. OMC).64(1,2). 1-8. 2018.

  • Oba, M., Naoi, Y., Ito, M., Masuda, T., Katayama, Y., Sakaguchi, S., Omatsu, T., Furuya, T., Yamasato, H., Sunaga, F., Makino, S., Mizutani, T., Nagai, M.: Metagenomic identification and sequence analysis of a Teschovirus A-related virus in porcine feces in Japan, 2014-2016. Infection, genetics and evolution. 66: 210-216, 2018. 

     

  • Masuda, T., Sunaga, F., Naoi, Y., Ito, M., Takagi, H., Katayama, Y., Omatsu, T., Oba, M., Sakaguchi, S., Furuya, T., Yamasato, H., Shirai, J., Makino, S., Mizutani, T., Nagai, M.: Whole genome analysis of a novel picornavirus related to the Enterovirus/Sapelovirus supergroup from porcine feces in Japan. Virus research. 257: 68-73, 2018.

     

  • Sakanoue, H., Nakano, T., Sano, K., Yasugi, M., Monma, C., Miyake, M.: Adherence of Clostridium perfringens spores to human intestinal epithelial Caco-2 cells. FEMS Microbiol Lett: Mar 1;365(5) fny016, 2018.

  • Kogiso, H., Hosogi, S., Ikeuchi, Y., Tanaka ,S., Shimamoto, C., Matsumura, H., Nakano, T., Sano, K., Inui, T., Marunaka, Y., Nakahari., T.: A low [Ca2+]i-induced enhancement of cAMP-activated ciliary beating by PDE1A inhibition in mouse airway cilia. Pflugers Arch-European Journal of Physiology. 469: 1215-1227, 2017.

  • Wu H, Nakano T, Suzuki Y, Ooi Y, Sano K. Enhancement of adherence of Helicobacter pylori to host cells by virus: possible mechanism of development of symptoms of gastric disease. Med.Mol.Morphol. 50:103-111. 2017.

  • Miyagi, K,  Sano, K and Hirai, I: Sanitary evaluation of domestic water supply facilities with storage tanks and detection of Aeromonas, enteric and related bacteria in domestic water facilities in Okinawa Prefecture of Japan. Water Res.  119: 171-177, 2017

  • Wu, H.: Examination of an alternative to uranyl acetate in immunoelectron microscopy for ultrathin sections of bacteria. Microscopy. 65:No. S1. 2016.

  • Wu, H.: Optimum number of bacterial cells for examination of localization of intrabacterial nanotransportation system by semiquantitative immunoelectron microscopy. Bull. OMC. 62:19-23. 2016.

  • Suzuki, Y., Chin, WX, Han, QE., Ichiyama, K., Lee, CH., Eyo, AW., Ebina, H., Takahashi, H.,Takahashi, C., Tan, BH., Hishiki, T., Ohba, K., Matsuyama, T., Koyanagi, Y., -Tan, YJ., Sawasaki, T., Chu, JJH., Vasudevan, SG., Sano, K.: Characterization of RyDEN (C19orf66) as an interferon-stimulated cellular inhibitor against dengue virus replication. PLoS Pathog 12(1): e1005357, 2016.

  • Okumura R., Kurakawa T.,Nakano T.,Kayama H.,Kinoshita M.,Motooka D., Gotoh K.,Kimura T.,Kamiyama N.,Kusu T., Ueda Y.,Wu H.,Iijima H.,Barman S.,Osawa H.,Matasuno H.,Nishimura J.,Ohba Y.,Nakamura S.,Iida T.,Yamamoto M.,Uemomoto E.,Sano K., Takeda K.,Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia. Nature 532:117-121.2016.

  • Miyagi K.,Hirai I.,Sano K. Distribution of Aeromonas species in environmental water used in daily life in Okinawa Prefecture, Japan. Environ Health Prev Med DOI:10.1007/s12199-016-0528-0.2016

  • Akiyama-Oda Y., Oda h. Multi-color FISH facilitates analysis of cell-type diversification and developemental gene regulation in the Parasteatoda spider embryo. Develop. Growth Differ.58:215-224, 2016.

  • Wu, H., Iwai, N., Nakano, T., Y., Ooi, Ishihara, S., Sano, K. Route of intrabacterial nanotransportation system for CagA in Helicobacter pylori. Med. Mol. Morphol. 48: 191-203, 2015.

  • Matsuzaki, Y., Wu, H., Nakano, T., Nakahari, T., and Sano, K.: ATP-association to intrabacterial nanotransportation system in Vibrio cholerae. Med.Mol.Morphol. 48: 225-234, 2015.

  • Nakano, T., Hayashi, H., Wu, H., Shimamoto, C., and Sano, K.: Disinfection potential of electrolyzed strongly acidic water against Mycobacteria: Conditions of dininfection and recovery of disinfection potential by re-electrolysis. Biomed. Res. (Tokyo) 36: 109-113, 2015.

  • Tanaka, S., Sugiyama, N., Takahashi, Y., Mantoku, D., Sawabe, Y., Kuwabara, H., Nakano, T., Shimamoto, C., Matsumura, H.,Marunaka, Y., and Nakahari, T.: PPARα autocrine regulation of Ca2+-regulated exocytosis in guinea pig antral mucous cells: NO and cGMP accumulation. Am. J. Physiol. Gastrointest. Liver Physiol. 307: G1169-G1179, 2014.

  • Wu, H., Nakano, T., Matsuzaki, Y., Ooi, Y., Kohno, T., Ishihara, S. and Sano, K.: A new type of intrabacterial nanotransportation system for VacA in Helicobacter pylori. Med.Mol.Morphol. 47: 224-232, 2014.

  • Dochi, T., Nakano, T., Mutsumi Inoue, M., Takamune, N., Shoji, S., Sano, K. and Misumi, S: Phosphorylation of human immunodeficiency virus type 1 capsid protein at serine 16, required for peptidyl-prolyl isomerase-dependent uncoating, is mediated by virion-incorporated extracellular signal-regulated kinase 2. J. Gen. Virol. 95, 1156–1166, 2014

  • 佐野浩一：病原体等安全管理技術認定の在り方．バムサジャーナル25(3): 1-2, 2013

  • 石原園子，笠松美恵，井村俊郎，片山友子：関西空港検疫所でのロスリバー熱相談事例．病原体微生物検出情報34(12): 378-380, 2013

  • 道重文子，口腔内の生体防御能に関する評価指標についての研究．大阪医大誌．72(3):　113-119, 2013

  • Harada, S., Tanaka, S., Takahashi, Y., Matsumura, H., Shimamoto, C., Nakano, T., Kuwabara, H., Sawabe, Y., and Nakahari, T.: Inhibition of Ca2+-regulated exocytosis by levetiracetam, a ligand for SV2A, in antral mucous cells of guinea pigs. Eur. J. Pharmacol., 721: 185-192, 2013.

  • Kobayashi, T., Hirose, J., Wu, H., Sano, K. Katsumata, T., Tsujibo, H., and Nakano, T.: Application of electrolysis for inactivation of an antiviral drug that is one of possible seletion pressure to drug-resistant influenza viruses. J. Virol. Methods, 194: 154-160, 2013.

  • Narumoto, O., Niikura, Y., Ishii, S., Morihara, H., Okashiro, S., Nakahari, T., Nakano, T., Matsumura, H., Shimamoto, C., Moriwaki, Y., Misawa, H., Yamashita, N., Nagase, T., Kawashima, K., and Yamashita, N.: Effect of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1) on airway epitherial cells.  Biochem. Biophys. Res. Commun., 438: 175-179, 2013.

  • Nakano, T., Hirose, J., Kobayashi, T., Hiro, N., Kondo, F., Tamai, H., Tanaka, K., and Sano, K.: Application of electrolysis to inactivation of antibacterials in clinical use. Ecotox. Environ. Safe. 90: 98-102, 2013.

  • Hirayama, T., Mizuno,Y., Takeshita, N., Kotaki, A., Tajima, S., Omatsu, T., Sano, K., Kurane, I. and Takasaki, T.: Detection of dengue virus genome in urine by real-time RT-PCR: a laboratory diagnostic method useful after disappearance of the genome in serum. J. Clin. Microbiol. 50(6): 2047-2052, 2012

  • Nakano, T., Aoki, H., Wu, H., Fujioka, Y., Nakazawa, E., and Sano, K.: Fine visualization of filamentous structures in the bacterial cytoplasm. J. Microbiol. Methods 90(1): 60-64, 2012

  • Matsushita Yamamoto, T., Nakano, T., Yamaguchi, M., Shimizu, M., Wu, H., Aoki, H., Rie Ota, R., Kobayashi, T and Sano, K.: Disinfective process of strongly acidic electrolyzed product of sodium chloride solution against Mycobacteria. Med. Molec. Morphol. 45: 199-205, 2012.

  • Kobayashi T., Hirose J, Sano K., Kato R, Ijiri Y., Takiuchi H., Tanaka K., Goto E., Tamai H. and Nakano T.: Application of electrolysis for detoxification of an antineoplastic in urine. Ecotox. Environ. Safe. 78, 123-127, 2012
  • Tamai K, Shiina M, Tanaka N, Nakano T, Yamamoto A, Kondo Y, Kakazu E, Inoue J, Fukushima K, Sano K, Ueno Y, Shimosegawa T and Sugamura K: Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway. Virology 422, 377-385, 2012
  • Nakahari, T., Nishimura, A., Shimamoto, C., Sakai, A., Kuwabata, H., Nakano, T., Tanaka, S., Kohda, Y., Matsumura, H., and Mori, H: The regulation of ciliary beat frequency by ovarian steroids in the guinea pig Fallopian tube: interactions between oestradiol and progesterone. Biomedical Research, 32: 321-328, 2011
  • Ooi,Y., Daikoku, E., Wu, H., Aoki, H., Morita, C., Nakano, T., Kohno, T., Takasaki, T. and Sano, K.: Morphology and infectivity of virus that persistently infected in AGS cell. Med. Molec. Morphol., 44：213-220, 2011
  • Yamamoto PS, Okawa K, Nakano T., Sano K., Ogawa K , Masuda T, Morikawa Y, Koyanagi Y, Suzuki Y,: Huwe1, a novel cellular interactor of Gag-Pol through integrase binding, negatively influences HIV-1 infectivity. Microbes Infect. 13(4): 339-49 2011
  • Ohishi M., Nakano T., Sakuragi S., Shioda T., Sano K., Sakuragi J.: The relationship between HIV-1 genome RNA dimerization, virion maturation and infectivity. Nucleic Acids Res., 39 (8), 3404-3417, 2010
  • Tamai K., Nakano T, Kakazu E., Kondo Y., Inoue J. Shiina M, Fukushima K, Hoshino T, Sano K, Ueno Y, Shimosegawa T, Sugamura K,: Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein. BBRC-10-4612, 2010
  • Nishimura A., Sakuma K., Shimamoto C., Ito S., Nakano T., Daikoku E., Ohmichi M., Ushiroyama T., Ueki M., Kuwabara H., Mori H. and Nakahari T.: Ciliary beat frequency controlled by estradiol and progesterone during ovarian cycle in guinea-pig Fallopian tube. Exp Phisiol 95: 819-828, 2010.
  • Sawabe Y., Shimamoto C., Sakai A., Kuwabara H., Saad A H., Nakano T., Takitani K., Tamai H., Mori H., Marunaka Y. and Nakahari T.: Peroxisome proliferation activation receptor alpha modulation of Ca2+-regulated exocytosis via arachidonic acid in guinea-pig antral mucous cells. Exp Phisiol 95: 858-868, 2010
  • 藤岡　良彦,　呉　紅,　佐野　浩一 酢酸ウラニル電子染色の代替法の検討 大阪医科大学雑誌　68, (1), 20-25. 2009
  • Suyama, M., Daikoku, E., Sano, K., and Morikawa, Y.: Reactivation from latency produces HIV particle budding at plasma membrane, accompanying CD44 upregulation and recruitment. Retrovirology 6:63, 2009

  • Aoki, H., Wu, H., Nakano, T., Ooi, Y., Daikoku, E., Kohno, T., Matsushita, T., Sano, K.: Nanotransportation system for cholera toxin in Vibrio cholerae O1. Med. Mol. Morphol. 42(1)40-46, 2009

  • Arai, Y., Nakano, T., Katayama, Y., Aoki, H., Hirayama, T., Ooi, Y., Eda, J., Imura, S., Kashiwagi, E. and Sano, K.: Epidemiological evidence of Multidrug-resistant Shigella sonnei colonization in India by sentinel surveillance in a Japanese quarantine station. J. Japn. Assoc. Infect. Diseases 82: 322-327, 2008

  • Ooi, Y., Hayashi A., Aoki, H., Eda, J., Hamada, M., Imura, S., Nakano, T., Sano, K. and Kashiwagi, E.: Viral titers in the sera of Dengue patients among travelers at the quarantine station of Kansai International Airport. Jpn. J. Infect. Diseases. 61: 329-330, 2008
  • Kobayashi T., Hirose J., Sano K, Hiro N., Ijiri Y, Tamai H., Takenaka H., Tanaka T., and Nakano T.: Evaluation of an electrolysis apparatus for inactivating antineoplastics in clinical wastewater. Chemosphere 72: 659-665, 2008
  • Sato, K., Aoki, J., Misawa, N., Daikoku, E., Sano, K., Tanaka, Y. and Koyanagi ,Y.: Modulation of Human immunodeficiency virus type 1 infectivity through incorporation of tetraspanin proteins. J. Virol. 82(2): 1021-1033, 2008
  • Miyazaki, H., Shiozaki, A., Niisato, N., Ohsawa, R., Itoi, H., Ueda, Y., Otsuji, E., Yamagishi, H., Iwasaki, Y., Nakano, T., Nakahari, T. and Marunaka, Y.:Chloride ions control the G1/S cell-cycle checkpoint by regulating the expression of p21 through a p53-independent pathway in human gastric cancer cells. Biochem. Biophys. Res. Commun.366: 506-512, 2008
  • Tanaka, K., Sano, K., Nakano, T., Yuba, K. and Kinoshita, M. : Suppression of alpha-smooth muscle actin expression by Interferon gamma in established myofibroblast cell lines. J. Interf. Cytok Res. 27:　835-839, 2007
  • Yuba, K., Sano, K., Nakano, T., Mori, H., Tanaka, K., Tanaka, K., Daikoku, E., Okada, Y., Kinoshita, M. and Abe, M. : Frequent establishment of long-term-cultured myofibroblast cell lines derived from Dupuytren’s nodules, which are implantable into nude mice. Bull.Osaka Med. Col. 53 : 123-132, 2007
  • Daikoku, E, Morita, C., Kohno, T. and Sano, K. : Analysis of morphology and infectivity of measles virus particles. Bull.Osaka Med. Col. 53 : 107-114, 2007
  • Yokoyama, I., Nakano, T., Morita, C., Arai, Y., Hirayama, T., Aoki, H., Hirose, J. and Sano, K. : Establishment of gold standard for electrolyzed sodium chloride solution in disinfection. Bull.Osaka Med. Col. 53 : 11-19, 2007
  • Iwakura, K., Wu, H., Nakano, T., Daikoku, E., Shimamoto, C., Katsu, K., and Sano, K. : Unique Enhancement of Multinuclear Giant Cell Formation in AGS Cell Line Infected with Helicobacter pylori. Bull.Osaka Med. Col. 53 : 1-9, 2007
  • Shimamoto, C., Nakanishi, Y., Katsu, K., Nakano, T., Kubota, T., Mori, H. and Nakahari, T.: Prostaglandin E2 release in gastric antral mucosa of guinea-pigs: basal PGE2 release by cyclo-oxygenase 2 and ACh-stimulated PGE2 release by cyclo-oxygenase 1. Exp. Phisiol. 91: 1015-1024, 2006
  • Murai, M., Fukumoto, H., Negoro, N., Sano, K., Nishimoto, M., Muraoka, H.,j Hazui, H., Morita, H., Hnafusa, T. : Evidence of active endocarditis, caused by Gemella morbillorum, related to acute embolic stroke. Int.J.Cardiol. 112 : e17-e18, 2006
  • Zin,NM, Nakano, T and Sano, K : The restriction fragment length polymorphism patterns and the presence of outer membrane protein gene in some Vibrio cholerae O1 and O139 atrains. J.Sci.Tech.Tropics 2 : 17-20, 2006
  • Wu, H., Nakano, T., Daikoku, E., Morita, C., Kohono, T., Lian, HH., Sano, K. : Intrabacterial proton-dependent CagA transport system in Helicobacter pylori. J.Med. Microbiol. 54 :1117-1125, 2005
  • Yamaguchi, S., Tashiro-Yamaji, J., Lee, K., Takahashi, T., Sano, K., Enco, Y., Nakanishi, M., Eguchi, A., Okada, T., Noma, H., Yamamoto, Y., Takenaka, H., Kubota, T., Yoshida, R. : IFN-γ : A cytokine essential for rejection of CTL-resistant, visu-infected cells. J. Interfer. Cytok.Res. 25 : 328-337, 2005
  • Hirose, J., Kondo, F., Nakano, T., Kobayashi, T., Hiro, N., Ando, Y., Takenaka, H. and Sano, K. : Inactivation of antineoplastics in clinical wasetewater by electrolysis. Chemosphere 60 :1081-1024, 2005
  • Mohan, S., Goto, T., Kohno,T., Nakano, T., Harada, F., Kiso, Y., Yoshioka, S. and Sano, K. : Evidence for the cellular uptake of anti-HIV-1 double drug KNI-1039. Bull.Osaka Med. Col. 51 : 50-60, 2005
  • Harada, F., Nakano, T., Kohono, T., Mohan, S., Taniguchi, H. and Sano, K. : RNA-dependent DNA polymerase (RT) activity of bacterial DNA polymerases. Bull.Osaka Med. Col. 51 : 35-41, 2005
  • Taniguchi, H., Nakano, T., Mori, K., Harada, F., Katayama, Y., Kamiya, K., Maruyama, H. and Sano, K. : Possibility of survey for Shigella endemic in a non-endemic area by molecular epidemiology. Epidemiol. Infect., 133 : 611-615, 2005
  • Nakajima, N., Nakano, T., Harada, F., Taniguchi, H., Yokoyama, I., Hirose, J., Daikoku, E. and Sano, K. : Disinfection of pooled tap water by reactivation of chlorine. J. Microbiol. Methods, 57 : 163-173, 2004
  • Lee, K., Takenaka, H., Yoneda, Y., Goto, T., Sano, K., Nakanishi, M., Eguchi, A., Okada, M., Tashiro, J., Sakurai, K., Kubota, T., and Yoshida, R. : Differential Susceptibility of Cells Expressing Allogeneic MHC or Viral Antigen to Killing by Antigen-Specific CTL. Microbiol. Immunol. 48 : 15-25. 2004.
  • Kitano, J., Kohno, T., Sano, K., Morita, C., Yamaguchi, M., Maeda, T. and Tanigawa, N : A novel electrolyzed sodium chloride solution for the disinfection of dried HIV-1. Bull. Osaka Med.Col. 48 : 29-36, 2003
  • Miyagi, K., Nakano, T., Yagi, T., Omura, K., Hanafusa, M., Nakano, Y., Honda, T. and Sano, K. : Survey of Vibrio cholerae O1 and survival over the winter in marine water of Port of Osaka. Epidemiol. Infect., 131 : 613-619, 2003
  • Tanaka, K., Sano, K., Tanaka, K., Kobayashi, M., Katsumura, K., Ikeda, T. and Abe, M. : Inhibition of induction of myofibroblasts by interferon-gamma in a human fibroblast cell line. Int. Immunopharmacol. 3 : 1273-1280, 2003
  • Okamoto, S., Kawabata, S., Nakagawa, I., Okuno, Y., Goto, T., Sano, K. and Hamada, S. : Influenza A virus-infected hosts boost an invasive type of Streptococcus pyogenes infections in mice. J. Virol. 77 : 4104-4112, 2003
  • Kawahata, T., Otake, T., Mori, H., Kojima, Y., Oishi, I., Oka, S., Fukumori, Y. and Sano, K. : A novel substance purified from Perilla frutescens Britton inhibits early stage of HIV-1 replication without blocking viral adsorption. Antivir. Chemistr. Chemother. 13 : 283-288, 2003
  • Hong, W., Sano, K., Morimatsu, S., Scott, D.R., Weeks, D.L., Sachs, G. Goto, T., Mohan, S., Harada, F., Nakajima, N. and Nakano, T. : Medium pH dependent redistribution of the urease of Helicobacter pylori. J. Medical Micribiol., 52 : 211-216, 2003
  • Katsumura, K., Kobayashi, M., Sano, K., Suzuki, K., Kusakabe, H., Tanaka, K., Abe, M. and Ikeda, T. : Spontaneous establishment of a novel human cell line derived from eye lens capsule epitherium. Bull.Osaka Med. Col. 1&2 : 27-34, 2002.
  • Odawara, F., Abe, H., Kohno, T., Nagai-Fujii, Y., Arai, K., Imamura, S., Misaki, H., Azuma, H., Idebuchi, K., Ideda, H., Mohan, S. and Sano, K. : A highly senseitive chemiluminescent reverse transcriptase assay for human immunodeficiency virus. J. Virol. Methods, 106 : 115-124, 2002
  • Sakuragi, S., Goto, T., Sano, K. and Morikawa, Y. : HIV type 1 Gag virus-like particle budding from spheroplasts of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA, 99 :7956-7961, 2002.
  • Kiura, H., Sano, K., Morimatsu, S., Nakano, T., Morita, C., Yamaguchi, M., Maeda, T. and Katsuoka, Y. : Bactericidal activity of electrolyzed acid water from solution containing sodium chloride at low concentration, in comparison with that at high concentration. J. Microbiol. Methods, 49 :285-293, 2002 （2001年度産学連携研究契約による）.
  • Kohno, T., Mohan, S., Goto, T., Morita, C., Nakano, T., Hong, W., Sangco, J.C.E., Morimatsu, S. and Sano, K. : A new improved method for the concentration of HIV-1 infective particles. J. Virol. Methods, 106 : 167-173, 2002
  • Miyagi, K., Takegaki, Y., Nakano, T., Nakano, Y. Honda, T. and Sano, K. : Frequency of failure to isolate Shigella spp. aby the direct plating technique and improvement of isolation by enrichment in selenite broth. Epidemiol. Infect., 127 : 375-379,2001
  • Mitsuishi Y., Kohno, T., Miyamoto, K., Odawara, F., Misaki, H. and Sano, K. : A direct measurement of polymerase activity of human hepatitis B virus in sera. Bull. Osaka Med. Col., 46 :17-23, 2001

  • Morimatsu, S., Yanagida, J., Imanishi, A., Nakano, T., Wu, H., Fujioka, Y., Morita, C., Goto, T., Fukuda Y., Shimoyama, T., Yamaguchi, N., and Sano, K.: Detection of spiral, large coccoid and small coccoid forms of Helicobacter pylori by a simple staining. Bull. Osaka Med. Col., 46 : 35-40, 2000

  • Matsumoto, H., Kimura, T., Hamawaki, T., Kumagai, A., Goto, T., Sano, K., Hayashi, Y. and Kiso, Y. : Design, synthesis and biological evaluation of anti-HIV double-drugs : Conjugates of HIV protease inhibitors with a reverse tanscriptase inhibitor through spontaneously cleavable linkers. Bioorg. Med. Chem., 9 :1589-1600, 2001
  • Kanemoto T., Kashiwada, Y., Kanbara, K., Gotoh, K., Yoshimori, M., Goto, T., Sano, K. and Nakashima, H. : Anti-human immunodeficiency virus activity of YK-FH312 (a Betulinic acid derivative), a novel compound blocking viral mutation. Antimicrob. Agents Chemother. 45 : 1225-1230, 2001.
  • Tanaka, K., Sano, K., Kobayashi, M., Katsumura, K., Ikeda, T. and Abe, M. : Determination of downregulation of a-smooth muscle actin in interferon-g-treated myofibroblast by a novel cell-capture enzyme immunoassay. Int. Immunopharmacol. 1 : 769-775, 2001.
  • Morikawa, Y., Kinoshita, A., Goto, T., Tomoda, H. and Sano, K. : Membrane relocation but not tight binding of human immunodeficiency virus type 1 Gag particles myristoylated in Escherichia coli. Virology, 283 : 343-352, 2001.
  • Miyagi, K., Ohmura, K., Ogawa, A., Hanafusa M., Nakano, Y., Morimatsu, S. and Sano, K. : Survival of Shiga toxin-producing Escherichia coli O157 in marine water and frequent detection of the Shiga toxin gene in marine water samples from an estuary port. Epidemiol. Infect., 126 : 129-133, 2001.
  • Goto, T., Kohno, T., Nakano, T., Fujioka, Y., Morita, C. and Sano, K. : An improved procedure of electron microscopic in situ hybridization for detecting adenovirus DNA.J. Electr. Microsc., 50 : 73-76, 2001.
  • Goto, T., Nakano, T., Kohno, T ., Morimatsu, S., Morita, C., Hong, W., Kiso, Y., Nakai, M. and Sano, K. : Targets of a protease inhibitor, KNI-272, in HIV-1-infected cells. J. Med. Virol., 63 : 203-209, 2001
  • Kobayashi, M., Sano, K., Katsumura, K., Kusakabe, H., Tanaka, K., Sugiyama, T., Doi, M., Abe, M. and Ikeda, T. : Determination of optimal condition for the immobilization of cells in a cell capture enzyme immunoassay (CC-EIA) by a simple Giemsa assay. J. Immunoass. Immnoc., 21 : 297-314, 2000.
  • Hong, W., Morimatsu, S., Goto, T., Kohno, T., Morita, C., Nakano, T., Fujioka, Y. and Sano, K. : Contrast-enhanced immunoelectron microscopy for Helicobacter pylori. J. Microbiol. Methods, 42 : 121-127, 2000.
  • Matsumoto, H., Hamawaki, T., Ota, H., Kimura, T., Goto, T., Sano,K., Hayashi, Y. and Kiso, S. : “Double-drugs”- A new class of prodrug form of an HIV protease inhibitor conjugated with a reverse transcriptase inhibitor by a spontaneouslly cleavable linker. Bioorg. Med.Chem. Lett., 10, 1227-1231, 2000.
  • Kusakabe, H., Iwasaki, H., Sano, K. and Kiyokane, K. : Expression of lung resistance protein in epithelioid sarcoma cell in vitro. Arch. Dermt. Res, 292 : 292-300, 2000
  • Morikawa, Y., Shibuya, M., Goto, T. and Sano, K. : In vitro processing of human immunodeficiency virus type 1 Gag virus-like particles. Virology, 272 : 366-374, 2000
  • Mirz K.B., Kameoka, M., Goto, T., Sano, K., Luftig, R.B. and Ikuta, K. : Fusion of uninfected T-cells occurs with immature HIV-1 protease-mutant, but not morphologically similar protease inhibitor derived particles. Virus Res. 66 : 131-137, 2000.
  • Morita, C., Sano, K., Morimatsu, S., Kiura,H., Goto, T., Kohno, T., Hong, W., Miyoshi, M., Iwasawa, A., Nakamura, Y., Tagawa, M., Yokosuka, O., Saisho, H., Maeda, T., and Katsuoka, Y. : Disinfective potential of electrolyzed solutions containing sodium chloride at low concentrations . J. Virol. Methods, 85 :163-174, 2000
  • Morikawa, Y., Goto, T. and Sano, K. : In vitro assembly of human immunodeficiency virus type1 Gag protein.J. Biol. Chem. 274 :27997-28002, 1999.
  • Kawabata, S., Kuwata, H., Nakagawa, I., Morimatsu, S., Sano, K. and Hamada, S. : Capsular hyaluronic acid of Group A Streptococci hampers their invasion into human pharyngeal epithelial cells. Microb. Pathogenesis 27 :71-80, 1999.
  • Miyagi, K., Sano, K., Morita, C., Imura, S., Morimatsu, S., Goto, T., Nakano, Y., Hashimoto, S., Matsumoto, Y., Maeda, K., Omura, K., Takarada, Y. and Honda, T. : An improved method for detecting faecal Vibrio cholerae by PCR of the toxin A gene. J. Med. Microbiol. 48 :883-889, 1999.
  • Kohno, T., Goto, T., Takasaki, T., Morita, C., Nakaya, T., Ikuta, K., Kurane, I., Sano, K. and Nakai, M. : Fine structure and morphogenesis of Borna Disease Virus. J. Virol. 73 :760-766, 1999.
  • Matsui, R., Komori, T., Namba, R., Shimizu, T., Sueyoshi, K., Sano, K. and Narabayashi, I. : In vitro uptake and release of TI-201 and Tc-99m MIBI in cultured tumor cells and effect of anticancer drug. Rad. Med. :16(3)187-194, 1998.
  • Goto, T., Kohno, T., Morita, C., Morimatsu, S., Sano, K.., Kimura, T., Fujii, J., Fujisawa, Y., Ikuta, K., and Nakai, M. : Localization of enzymatic and regulatory proteins in HIV-1 particles. 12th World AIDS Conf. 1 : 37-40, 1998.

  • Kohno, T., Fujioka, Y., Goto, T., Morimatsu, S., Morita, C., Nakano, T. and Sano, K. : Contrast-enhancement for the image of human immunodeficiency virus from ultrathin sections by immuno electron microscopy. J.Virol. Methods, 72 :137-143, 1998.

  • Kato, H., Yonezawa, T., Kosaka, R., Shirai, H., Sano, K., Abe, M. : An improved methods for the evaluation of the effects of laser irradiation on cultured osteoblastic cells. Bull.Osaka Med. Col. 44 : 19-26, 1998
  • Kato, H., Yonezawa, T., Kosaka, R., Shirai, H., Sano, K., Abe, M. : An improved methods for the evaluation of the effects of laser irradiation on cultured osteoblastic cells. Bull.Osaka Med. Col. 44 : 19-26, 1998
  • Takasaki, T., Ohkawa, N., Sano, K., Morimatsu, S., Nakano, T., Nakai, M., Ymaguchi, J., Kurane, I. : Electron microscopic study of human herpesvirus 6-infected human T cell lines superinfected with human immunodeficiency virus type 1. Acta Virol. 41 : 221-229, 1997
  • Nakamura, T., Masuda, T., Goto, T., Sano, K., Nakai, M., Harada, S. : Lack of infectivity of HIV-1 integrase zinc finger-like domain mutant with morphologically normal maturation. Biochem. Biophys. Res. Cmm.. 239 : 715-722, 1997
  • Kawano Y, Tanaka Y, Misawa N, Tanaka R, Kira JI, Kimura T, Fukushi M, Sano K, Goto T, Nakai M, Kobayashi T, Yamamoto N, Koyanagi Y : Mutational analysis of HIV-1 accessory genes : Requirement of site in nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo.
    J. Virol. 71 : 8456-8466, 1997
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